7-Benzyl-4-hydroxy-3-methyl-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester → 7-Benzyl-4-chloro-6,7-dihydro-3-methyl-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

HRID 902528노트

반응식

HRID 902528 반응식
[CH2:1](OC(C1C(=O)N(CC2C=CC=CC=2)C2SC=C(C)C=2C=1O)=O)C.[CH2:25]([N:32]1[C:37](=[O:38])[C:36]([C:39]#[N:40])=[C:35]([Cl:41])[C:34]2[CH:42]=[CH:43][S:44][C:33]1=2)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([N:32]1[C:37](=[O:38])[C:36]([C:39]#[N:40])=[C:35]([Cl:41])[C:34]2[C:42]([CH3:1])=[CH:43][S:44][C:33]1=2)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

3

반응물 2

HCID 597020557-Benzyl-4-hydroxy-3-methyl-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl esterHCID 693140757-Benzyl-4-chloro-6,7-dihydro-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

생성물 1

HCID 597020577-Benzyl-4-chloro-6,7-dihydro-3-methyl-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile수율 87%

실험 절차

This compound was prepared from 7-benzyl-4-hydroxy-3-methyl-6-oxo-6,7-dihydro-thieno[2,3-b]pyrdine-5-carboxylic acid ethyl ester (61) by applying a similar procedure as described for the preparation of 7-benzyl-4-chloro-6,7-dihydro-6-oxo-thieno[2,3-b]pyrdine-5-carbonitrile (64). Yield 87%. 1H-NMR (DMSO-d6): δ 2.48 (s, 3H), 5.36 (s, 2H), 7.14 (s, 1H), 7.32 (m, 5H) ppm; EIMS m/z 315 (M+1).

출처 및 근거

ORD 기록
ord-bd2a4fad5e08416d8a92d2d02783e55a
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365200B2

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