Pyridine → 3-Bromo-6-quinolinecarbonitrile

HRID 902569노트

반응식

HRID 902569 반응식
[Br:1]Br.N1C=CC=CC=1.[C:9]([C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][CH:15]=[CH:14]2)#[N:10]>C(Cl)(Cl)(Cl)Cl>[Br:1][C:15]1[CH:16]=[N:17][C:18]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:9]#[N:10])=[CH:20][CH:19]=2

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24408BromineHCID 592995Quinoline-6-carbonitrile

생성물 1

HCID 181862093-Bromo-6-quinolinecarbonitrile

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

In an amount of 37.8 mg of 6-cyanoquinoline (Justus Liebigs Ann. Chem., 1966, 699, 98-106) was dissolved in 1 ml of carbon tetrachloride, added with 13 μl of bromine, and then stirred under reflux. After 2 hours, the reaction mixture was added with 20 μl of pyridine, and further stirred for 23 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate (4:1)) to obtain 34.8 mg of the title compound.

후처리

  1. temperatureunder reflux
  2. stirringfurther stirred for 23 hours
  3. temperatureunder reflux
  4. concentrationThe reaction mixture was concentrated under reduced pressure
  5. customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate (4:1))

출처 및 근거

ORD 기록
ord-f178da4f9adc49b598327e4d0468bb40
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365174B2

반응 노트

불러오는 중…