4-Toluenesulfonyl chloride → (3-[4-(Toluene-4-sulfonyloxy)butyl]phenyl}acetic acid methyl ester

HRID 902623노트

반응식

HRID 902623 반응식
[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH:6]=1.[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>N1C=CC=CC=1.O>[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH3:27])=[CH:18][CH:19]=2)(=[O:25])=[O:24])[CH:6]=1

참가 물질

5

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 59745064{3-[4-Hydroxybutyl]phenyl)acetic acid methyl ester

생성물 1

HCID 86598282(3-[4-(Toluene-4-sulfonyloxy)butyl]phenyl}acetic acid methyl ester수율 63.4%

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

실험 절차

A solution of {3-[4-hydroxybutyl]phenyl)acetic acid methyl ester (300 mg, 1.35 mmol) and p-toluenesulfonyl chloride (513 mg, 2.7 mmol) in pyridine (5 ml) was stirred at RT for 18 hr. The reaction was diluted with water (50 ml) and extracted with diethyl ether. The organic extracts were washed with water and cold 1N HCl, dried, and the solvent evaporated to give the title compound as an oil (322 mg, 63%). MS (ESI) 377.3 (M+H)+.

후처리

  1. extractionextracted with diethyl ether
  2. washThe organic extracts were washed with water and cold 1N HCl
  3. customdried
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-ce9dc71d2f20480da1aa9df1808db461
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365085B2

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