Methanesulfonic Acid → (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propyl}-amine dimesylate salt

HRID 902651노트

반응식

HRID 902651 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[C:12]([OH:14])[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:15]1([CH:21]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:22][N:23]([CH2:36][CH2:37][CH2:38]O)[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[C:26]=2[Cl:35])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.OC1C=C(C=CC=1)CC1N(COCC)N=NN=1.BrCCCO.[CH3:68][S:69]([OH:72])(=[O:71])=[O:70]>ClCCl>[S:69]([OH:72])(=[O:71])(=[O:70])[CH3:68].[S:69]([OH:72])(=[O:71])(=[O:70])[CH3:68].[Cl:35][C:26]1[C:27]([C:31]([F:32])([F:33])[F:34])=[CH:28][CH:29]=[CH:30][C:25]=1[CH2:24][N:23]([CH2:22][CH:21]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:36][CH2:37][CH2:38][O:14][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([N:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)[N:13]=1

참가 물질

7

반응물 5

HCID 6395Methanesulfonic AcidHCID 123083-Bromo-1-propanolHCID 577571173-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propan-1-olHCID 688254685-(3-Hydroxy-benzyl)-ethoxymethyl-1,2,3,4-tetrazoleHCID 178480672HCID 178480672, 화합물

생성물 1

HCID 86598286(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propyl}-amine dimesylate salt

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Following the procedure of Example 6(d), except 6-(4-methyl-piperazin-1-yl)-pyridin-2-ol and N-(2,2-Diphenylethyl)-N-(3-hydroxy-propyl)-N-(2-chloro-3-trifluoromethyl-benzyl)amine were used instead of 5-(3-hydroxy-benzyl)-ethoxymethyl-1,2,3,4-tetrazole and 3-bromo-propanol in step 6(d), the title compound was synthesized as the free base. The tertiaryamine was then dissolved in dichloromethane and two equivalents of methanesulfonic acid were added to afford the title compound as the dimesylate salt, 47 mg (19% yield), as a white solid. MS (ESI) 623.4 (M+).

후처리

  1. customthe title compound was synthesized as the free base

출처 및 근거

ORD 기록
ord-69d7d342c37b44f9a7e3b40a2974405e
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365085B2

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