4-Toluenesulfonyl chloride → 3-Chloropropyl p-toluenesulfonate

HRID 902720노트

반응식

HRID 902720 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][OH:5].[S:6](Cl)([C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1)(=[O:8])=[O:7]>N1C=CC=CC=1.O>[S:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])([C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1)(=[O:8])=[O:7]

참가 물질

5

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 123133-Chloro-1-propanol

생성물 1

HCID 694343-Chloropropyl p-toluenesulfonate

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

실험 절차

A solution of 3-chloro-1-propanol (1.88 g, 20 mmole) in 20 ml of pyridine was treated at 0° with tosyl chloride (7.6 g, 40 mmole). The solution was warmed to 23°, and stirred 16 hours. The reaction was diluted with 100 mL of H2O and stirred for 90 minutes, and extracted with Et2O. The extracts were washed with 1N HCl, dried, and the solvents thoroughly removed, and gave the titled product, 2.3 g (46%). MS (ESI) 188 (MH+).

후처리

  1. temperatureThe solution was warmed to 23°
  2. stirringstirred for 90 minutes
  3. extractionextracted with Et2O
  4. washThe extracts were washed with 1N HCl
  5. customdried
  6. customthe solvents thoroughly removed

출처 및 근거

ORD 기록
ord-2e0a2bb4065b47a0ace90b4fc7edbe3c
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365085B2

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