Propionic Acid → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamide

반응식

[C:1](O)(=[O:4])CC.[Cl:6][C:7]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:8]=1[CH2:9][NH:10][C:11](=[O:21])[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1Cl)[CH3:13]>>[Cl:6][C:7]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:8]=1[CH2:9][NH:10][C:11](=[O:21])[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:4][CH3:1])[CH3:13]

참가 물질

반응물 2

HCID 1032Propionic Acid

HCID 69254638N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide

생성물 1

HCID 69251127N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamide수율 42%

실험 절차

The titled compound was prepared from 22-methoxyphenyl)propionic acid in 42% yield in the same manner as the preparation of N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide in Example 184b. MS (ESI) 372 (MH+).

출처 및 근거

ORD 기록: ord-0975714eff3246cfbe4c077f790f32f4
출처 데이터셋: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07365085B2

반응 노트

불러오는 중…