Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 3-methoxy-2-(methoxymethyl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-Propenoic acid, 2-(bromomethyl)-, methyl ester | HCID 521093 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Methyl 3-methoxy-2-(methoxymethyl)propanoate | HCID 22934772 | — |
반응 단계
Sodium methoxide (1.21 g) was added to a solution of methyl 2-(bromomethyl)acrylate (1.0 ml) in methanol (10 ml), and the mixture was heated under reflux for 26 hours. After cooling, the reaction mixture was diluted with diethyl ether, and precipitate was collected by filtration and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4) to obtain the title compound (726 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07365205B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-2380bbf5a74c4fafaa8e79e6e211fbcd |
| 출처 메모 | uspto-grants-2008_04 |