2-Chloroethyl N-(2-chloro-4-nitrophenyl)carbamate → 3-(2-Chloro-4-nitrophenyl)-2-oxazolidinone

HRID 902999노트

반응식

HRID 902999 반응식
C[O-].[Na+].[Cl:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[NH:14][C:15](=[O:20])[O:16][CH2:17][CH2:18]Cl>CO.C(O)C>[Cl:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[N:14]1[CH2:18][CH2:17][O:16][C:15]1=[O:20]

참가 물질

5

반응물 2

HCID 3107132-Chloroethyl N-(2-chloro-4-nitrophenyl)carbamateHCID 10942334Sodium Methoxide

생성물 1

HCID 233373183-(2-Chloro-4-nitrophenyl)-2-oxazolidinone

시약·촉매·용매 2

HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

A solution of 11.25 g of sodium methoxide in 50 ml of methanol was added drop-by-drop to a stirred solution of 58.0 g of 1A in 400 ml of ethanol. The mixture was refluxed for 5 minutes, then the volatile materials were evaporated under reduced pressure. The residue was treated with water and extracted with ether. The extract was dried and concentrated under reduced pressure. The residue was cooled and filtered to give 3-(2-chloro-4-nitrophenyl)-2-oxazolidinone (1B), as a white solid, mp: 94°-96° C.

후처리

  1. temperatureThe mixture was refluxed for 5 minutes
  2. customthe volatile materials were evaporated under reduced pressure
  3. additionThe residue was treated with water
  4. extractionextracted with ether
  5. customThe extract was dried
  6. concentrationconcentrated under reduced pressure
  7. temperatureThe residue was cooled
  8. filtrationfiltered

출처 및 근거

ORD 기록
ord-0347dc0460dd46d2895dd2d891fb1b40
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04226612

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