N-methoxy-N-methylcarbamoyl chloride → N'-(3-chloro-4-(2-oxo-3-oxazolidinyl)phenyl)-N-methoxy-N-methylurea

HRID 903001노트

반응식

HRID 903001 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][O:10][C:9]2=[O:13])=[C:4]([Cl:14])[CH:3]=1.[CH3:15][O:16][N:17]([CH3:21])[C:18](Cl)=[O:19]>C(N(CC)CC)C>[Cl:14][C:4]1[CH:3]=[C:2]([NH:1][C:18](=[O:19])[N:17]([O:16][CH3:15])[CH3:21])[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:12][CH2:11][O:10][C:9]1=[O:13]

참가 물질

4

반응물 2

HCID 2734926N-methoxy-N-methylcarbamoyl chlorideHCID 233373153-(4-Amino-2-chlorophenyl)-2-oxazolidinone

생성물 1

HCID 23337319N'-(3-chloro-4-(2-oxo-3-oxazolidinyl)phenyl)-N-methoxy-N-methylurea

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

10.1 g of triethyamine was added to the solution of 1C, then 13.6 g of N-methoxy-N-methylcarbamoyl chloride was added drop-by-drop. After 12 hours at room temperature, the mixture was washed with water and extracted with ether. The extract was dried and the ether was evaporated under reduced pressure. The residue was chromatographed over silica gel to give 1, as a white solid, mp: 151°-153° C.

후처리

  1. washthe mixture was washed with water
  2. extractionextracted with ether
  3. customThe extract was dried
  4. customthe ether was evaporated under reduced pressure
  5. customThe residue was chromatographed over silica gel
  6. customto give 1

출처 및 근거

ORD 기록
ord-be16dce8df8346fbb304bce5a1408b3f
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04226612

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