N-acetyl-2-imidazolinone → 1-Acetyl-2-[1-(3-Trifluoromethylphenyl)-5-pyrazolyl] amino-2-imidazoline

반응식

[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:5]=[CH:4][CH:3]=1.[C:17]([N:20]1[CH2:24][C:23](=O)[N:22]=[CH:21]1)(=[O:19])[CH3:18]>>[C:17]([N:20]1[CH2:24][CH2:23][N:22]=[C:21]1[NH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:5]=[CH:4][CH:3]=1)(=[O:19])[CH3:18]

참가 물질

반응물 2

HCID 22350258N-acetyl-2-imidazolinone

HCID 433167702-(3-Trifluoromethylphenyl)-2H-pyrazol-3-ylamine

생성물 1

HCID 570896611-Acetyl-2-[1-(3-Trifluoromethylphenyl)-5-pyrazolyl] amino-2-imidazoline

실험 절차

5-Amino-1-(3-trifluoromethylphenyl) pyrazole (19.0 g.) and 1-acetyl-2-imidazolinone (12.9 g.) were reacted as described in Example I to give 16.85 g. product, mp 194°-197°.

후처리

customto give 16.85 g

출처 및 근거

ORD 기록: ord-e743bbfe155d410c9fd09163a03bd851
출처 데이터셋: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04226773

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