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Dimethylamine → [(2-Chloro-6-fluoro-phenyl)-(2-phenyl-1H-indol-3-yl)-methyl]-dimethylamine

HRID 9032
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인쇄 미리보기

반응식

HRID 9032 반응식
[C:1]1([C:7]2[NH:8][C:9]3[C:14]([CH:15]=2)=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[Cl:17][C:18]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:19]=1[CH:20]=[N+:21]([CH3:23])[CH3:22].ClC1C=CC=C(F)C=1C=O.CNC>>[Cl:17][C:18]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:19]=1[CH:20]([N:21]([CH3:23])[CH3:22])[C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 674DimethylamineHCID 136982-PhenylindoleHCID 678472-Chloro-6-fluorobenzaldehydeHCID 21985312(2-Chloro-6-fluoro-benzylidene)-dimethylammonium chloride

생성물 1

HCID 21985288[(2-Chloro-6-fluoro-phenyl)-(2-phenyl-1H-indol-3-yl)-methyl]-dimethylamine

실험 절차

The preparation was carried out in accordance with general synthesis instructions 4 from 2-phenylindole and (2-chloro-6-fluoro-benzylidene)-dimethyl-ammonium chloride, which had been prepared in accordance with example 24 from 2-chloro-6-fluoro-benzaldehyde and dimethylamine.

출처 및 근거

ORD 기록
ord-ab06589450384aad9d4c3c244b329c3c
출처 데이터셋
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07091220B2

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