Methyl isothiocyanate → N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea

반응식

CN=C=S.[S:5]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][CH2:12][CH2:13][NH2:14])=[N:6]1.[CH3:15][N:16]([CH3:22])[CH2:17][CH2:18][N:19]=[C:20]=[S:21]>>[CH3:15][N:16]([CH3:22])[CH2:17][CH2:18][NH:19][C:20]([NH:14][CH2:13][CH2:12][NH:11][CH2:10][C:7]1[CH:8]=[CH:9][S:5][N:6]=1)=[S:21]

참가 물질

반응물 3

HCID 11167Methyl isothiocyanate

HCID 3853726(2-Isothiocyanatoethyl)dimethylamine

HCID 20557777N-(3-isothiazolylmethyl)ethylenediamine

생성물 1

HCID 20557944N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea

실험 절차

By the procedure of Example 40(a) (ii), N-(3-isothiazolylmethyl)ethylenediamine is reacted with 2-dimethylaminoethyl isothiocyanate to give N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea. Reacting with hydrobromic acid gives the hydrobromide salt.

출처 및 근거

ORD 기록: ord-533391c1cc394d0186dc4bd87ed182c5
출처 데이터셋: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04226874

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