Sodium Bicarbonate → Ethyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

HRID 903309노트

반응식

HRID 903309 반응식
C(=O)(O)[O-].[Na+].Cl.[CH2:7]([O:9][C:10](=[O:13])[CH2:11][NH2:12])[CH3:8].[CH:14]1([CH3:26])[CH2:19][CH2:18][CH:17]([CH:20]([CH3:22])[CH3:21])[CH:16]([C:23](Cl)=[O:24])[CH2:15]1>O.CCOCC>[CH2:7]([O:9][C:10](=[O:13])[CH2:11][NH:12][C:23]([CH:16]1[CH:17]([CH:20]([CH3:22])[CH3:21])[CH2:18][CH2:19][CH:14]([CH3:26])[CH2:15]1)=[O:24])[CH3:8]

참가 물질

6

반응물 3

HCID 516892Sodium BicarbonateHCID 2723640Glycine ethyl ester, hydrochlorideHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

생성물 1

HCID 11521869Ethyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

Sodium bicarbonate (8.4 g., 0.1 mole) and glycine ethyl ester hydrochloride (7 g. 0.05 mole) were dissolved in water (100 ml.), and a solution of p-menth-3-oyl chloride (10 g., 0.05 mole) in ether (50 ml.) was added and the mixture stirred vigorously at room temperature for 2 hours. At the end of this time the other layer was separated and dried (MgSO4). Removal of the solvent left an oily solid (12.3 g.) This was distilled under reduced pressure to yield N-p-menth-3-oylglycine ethyl ester, bp. 150°-2°/0.1 mm. as a colourless liquid which rapidly solidified.

후처리

  1. customAt the end of this time the other layer was separated
  2. dry with materialdried (MgSO4)
  3. customRemoval of the solvent
  4. waitleft an oily solid (12.3 g.)
  5. distillationThis was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-dfefc25f2562433f8e14859e6370921a
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04226988

반응 노트

불러오는 중…