2-Pentanamine → N-(1-methylbutyl)-4-(methylsulfonyl)-2,6-dinitro-m-toluidine

HRID 903483

반응식

HRID 903483 반응식
Cl[C:2]1[C:3]([N+:16]([O-:18])=[O:17])=[C:4]([CH3:15])[C:5]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH2:19][CH:20]([CH2:22][CH2:23][CH3:24])[CH3:21]>C1C=CC=CC=1>[CH3:21][CH:20]([NH:19][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([CH3:14])(=[O:13])=[O:12])=[C:4]([CH3:15])[C:3]=1[N+:16]([O-:18])=[O:17])[CH2:22][CH2:23][CH3:24]

참가 물질

4

반응물 2

HCID 122462-PentanamineHCID 23335973HCID 23335973, 화합물

생성물 1

HCID 23335968N-(1-methylbutyl)-4-(methylsulfonyl)-2,6-dinitro-m-toluidine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture of 3-chloro-6-(methylsulfonyl)-2,4-di-nitrotoluene (10.0 g., 0.034 mole) and 2-aminopentane (6.1 g. 0.07 mole) is refluxed in benzene (75 ml.) for 4 hours. After standing overnight, the mixture is successively washed with dilute hydrochloric acid, water, a 5% aqueous potassium carbonate solution and finally water. The mixture is then dried over magnesium sulfate. Removal of the magnesium sulfate and solvent leaves the desired product as a yellow oil which readily crystallized on cooling. The crude product is recrystallized from ethanol to give 9.5 grams with m.p. 85°-88° C.

후처리

  1. washthe mixture is successively washed with dilute hydrochloric acid, water
  2. dry with materialThe mixture is then dried over magnesium sulfate
  3. customRemoval of the magnesium sulfate and solvent

출처 및 근거

ORD 기록
ord-894ae7259c644d92a7d8c2883be4ed37
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04227913

연결된 노트

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