Glutaric Acid → N-methyl-N-(4-carboxybutyryl)-tryptamine

HRID 903595

반응식

[C:1]([OH:9])(=[O:8])[CH2:2][CH2:3][CH2:4][C:5]([OH:7])=O.[CH3:10][NH:11][CH2:12][CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1>>[CH3:10][N:11]([C:5](=[O:7])[CH2:4][CH2:3][CH2:2][C:1]([OH:9])=[O:8])[CH2:12][CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1

참가 물질

반응물 2

HCID 743Glutaric Acid

HCID 6088Methyltryptamine

생성물 1

HCID 23336462N-methyl-N-(4-carboxybutyryl)-tryptamine수율 75%

반응 조건

온도: 150 °C

실험 절차

6.6 g of glutaric acid were added to 8.70 g of N-methyl-tryptamine (i.e., 3-(2-methylaminoethyl)-indole), and the mixture was heated at 150° C. under reduced pressure for 2 hours. After the reaction was completed, the product was recrystallized from a mixture of ethyl acetate and n-hexane. 10.8 g of N-methyl-N-(4-carboxybutyryl)-tryptamine (i.e., 3-[2-(N-methyl-4-carboxybutanamido)ethyl]-indole) were thereby obtained. M.p. 125°-126° C. Yield: 75.0%

후처리

customthe product was recrystallized from a mixture of ethyl acetate and n-hexane

출처 및 근거

ORD 기록: ord-ddfd82643c5d4248865fa931796885bb
출처 데이터셋: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04228168

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