2-Oxoadipic acid → 1,2,3,4-Tetrahydro-1-carboxy-1-(3-carboxypropyl)-2-ethyl-beta-carboline

HRID 903604

반응식

HRID 903604 반응식
[CH2:1]([NH:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1)[CH3:2].O=[C:16]([CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:17]([OH:19])=[O:18]>C1C=CC=CC=1.O1CCOCC1>[C:17]([C:16]1([CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:7]2[NH:8][C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:6]=2[CH2:5][CH2:4][N:3]1[CH2:1][CH3:2])([OH:19])=[O:18]

참가 물질

5

반응물 2

HCID 712-Oxoadipic acidHCID 6092N-Ethyltryptamine

생성물 1

HCID 233365071,2,3,4-Tetrahydro-1-carboxy-1-(3-carboxypropyl)-2-ethyl-beta-carboline수율 40%

시약·촉매·용매 2

HCID 241Benzene용매HCID 312751,4-Dioxane용매

실험 절차

5 g of N-ethyl-tryptamine (i.e., 3-(2-ethylaminoethyl)-indole) were dissolved in 100 ml of absolute benzene, and a solution of 4.70 g of α-keto-adipic acid in 50 ml of absolute dioxane was added thereto at room temperature. The mixture was refluxed for 20 hours. After the reaction was completed, the mixture was evaporated to remove solvent. The residue thus obtained was recrystallized from ethanol, whereby 3.51 g of 1,2,3,4-tetrahydro-1-carboxy-1-(3-carboxypropyl)-2-ethyl-β-carboline were obtained. Yield: 38.0%

후처리

  1. customat room temperature
  2. temperatureThe mixture was refluxed for 20 hours
  3. customthe mixture was evaporated
  4. customto remove solvent
  5. customThe residue thus obtained
  6. customwas recrystallized from ethanol

출처 및 근거

ORD 기록
ord-82daf5f83fa549d59bd1c96c58e2bfd8
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04228168

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