Water → 4-(3'-Azidopropyl)-piperidine

HRID 903863

반응식

HRID 903863 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].Br.Br[CH2:7][CH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.O>CO>[N:1]([CH2:7][CH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[N+:2]=[N-:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 135032154-(3-Bromopropyl)piperidine hydrobromide

생성물 1

HCID 135032204-(3'-Azidopropyl)-piperidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium azide (1 g) was added to a mixture of 4-(3'-bromopropyl)-piperidine hydrobromide (2 g), water (7 ml) and methanol (7 ml). The pH of the mixture was adjusted to 6.3, and the resulting solution was refluxed for 2 hours. After cooling, methanol was evaporated, 30 percent aqueous sodium hydroxide was added and the mixture was extracted several times with ether. The ether extracts were dried and evaporated to leave the desired compound as an oil. The IR-spectrum (CHCl3) showed strong bands at 2925, 2100 and 1450 cm-1.

후처리

  1. temperaturethe resulting solution was refluxed for 2 hours
  2. temperatureAfter cooling
  3. custommethanol was evaporated
  4. addition30 percent aqueous sodium hydroxide was added
  5. extractionthe mixture was extracted several times with ether
  6. dry with materialThe ether extracts were dried
  7. customevaporated

출처 및 근거

ORD 기록
ord-806b04d0240c4ed3bee89453fef8cddb
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04229443

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