Water → 2-(azepan-4-yl)ethanol

HRID 903866노트

반응식

HRID 903866 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([CH2:12][CH:13]1[CH2:20][CH2:19][CH2:18][NH:17][C:15](=O)[CH2:14]1)(OCC)=[O:8].O>O1CCCC1>[OH:8][CH2:7][CH2:12][CH:13]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:15][CH2:14]1

참가 물질

5

반응물 3

HCID 962WaterHCID 20528706HCID 20528706, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 205287192-(azepan-4-yl)ethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred slurry of lithium aluminium hydride (5.70 g) in dry tetrahydrofuran (100 ml) was added β-carbethoxymethyl-caprolactam (10.3 g) in dry tetrahydrofuran (150 ml) over a period of 30 minutes. The mixture was refluxed for 2.5 hours, cooled and treated very slowly with water. The precipitate was filtered off and the filtrate was evaporated to yield the title compound as a viscous oil, which was used in the next step without purification.

후처리

  1. temperatureThe mixture was refluxed for 2.5 hours
  2. temperaturecooled
  3. filtrationThe precipitate was filtered off
  4. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-1937b8dea38e40008edd64b21d53b947
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04229443

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