3,5-Dichlorophenyl isocyanate → 2-Ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl ester

HRID 903889노트

반응식

HRID 903889 반응식
[CH3:1][O:2][C:3]([C:5]1([CH2:10][CH3:11])[NH:9][CH2:8][CH2:7][S:6]1)=[O:4].[Cl:12][C:13]1[CH:14]=[C:15]([N:20]=[C:21]=[O:22])[CH:16]=[C:17]([Cl:19])[CH:18]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1([CH2:10][CH3:11])[N:9]([C:21](=[O:22])[NH:20][C:15]2[CH:16]=[C:17]([Cl:19])[CH:18]=[C:13]([Cl:12])[CH:14]=2)[CH2:8][CH2:7][S:6]1)=[O:4]

참가 물질

4

반응물 2

HCID 944603,5-Dichlorophenyl isocyanateHCID 217820732-Ethyl thiazolidine-2-carboxylic acid methyl ester

생성물 1

HCID 539706522-Ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl ester수율 78.4%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 0.62 g of the 2-ethyl thiazolidine-2-carboxylic acid methyl ester thus obtained, 0.66 g of 3,5-dichlorophenyl isocyanate and 10 ml of toluene was stirred at room temperature for 1 hour. Then, the precipitate was filtered to give 1.00 g (yield 77.8%) of 2-ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl ester with a melting point of 187°-188° C. The results of the elementary analysis were as follows: Found (calculated in parentheses): C 46.48% (46.29%), H b 4.35% (4.44%), N 7.50% (7.71%), Cl 19.86% (19.52%).

후처리

  1. customthus obtained
  2. filtrationThen, the precipitate was filtered

출처 및 근거

ORD 기록
ord-1e6abf34231043f49e5b3cbe2b23f20a
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04229461

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