Ammonia → 4-Benzyloxy-2-carbamoyl-6-methyl indole

HRID 903923노트

반응식

HRID 903923 반응식
[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=O)[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:24]>CO>[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19](=[O:21])[NH2:24])[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 23335518Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate

생성물 1

HCID 233355554-Benzyloxy-2-carbamoyl-6-methyl indole수율 46%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

20.0 g 4-benzyloxy-2-ethoxycarbonyl-6-methyl indole (see preparation of the primary products in connection with Example 1) are heated together with 200 ml each of methanol and liquid ammonia in the autoclave for 16 hours, to 100° C. The solution is evaporated and the residue is chromatographed on silica gel (fluxing agent: chloroform/methanol 98:2). There is obtained 8.5 g (~46% of theory) 4-benzyloxy-2-carbamoyl-6-methyl indole; m.p. 185°-187° C.

후처리

  1. custompreparation of the primary products in connection with Example 1)
  2. customThe solution is evaporated
  3. customthe residue is chromatographed on silica gel (fluxing agent: chloroform/methanol 98:2)

출처 및 근거

ORD 기록
ord-bf0eb90eac3a4c789bc499fa9de57ff3
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04229464

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