Potassium Hydroxide → 4-(Benzyloxy)-6-methylindole-2-carboxylic Acid

HRID 903925노트

반응식

HRID 903925 반응식
[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=[O:20])[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=[O:20])[NH:13]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 23335518Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate

생성물 1

HCID 219043124-(Benzyloxy)-6-methylindole-2-carboxylic Acid수율 95%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

31.0 4-benzyloxy-2-ethoxycarbonyl-6-methyl indole (see preparation of the primary products in connection with Example 1) are heated to boiling in a mixture of 100 ml ethanol and 100 ml water during addition of 7.0 potassium hydroxide, for 2 to 3 hours. The ethanol is then evaporated in vacuum and the remaining, water alkaline solution is acidified with conc. hydrochloric acid. The resulting precipitate is aspirated, thoroughly washed with water and dried. There is obtained 27.6 g (~95% of theory) 4-benzyloxy-2-carboxy-6-methyl indole; m.p. 178°-180° C.

후처리

  1. custompreparation of the primary products in connection with Example 1)
  2. temperatureare heated
  3. customThe ethanol is then evaporated in vacuum
  4. washthoroughly washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-26c714820cd14c3caadd591155259e34
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04229464

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