Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 904167생성일: 2026년 10월 26일
creatinine → 1-(5-Methyl-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea
https://huagongshe.com/reaction/904167
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | creatinine | HCID 588 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Isocyanato-5-methylthiophene | HCID 11629619 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(5-Methyl-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea | HCID 136129176 | 74.7% |
반응 단계
To 1.44 g (12.8 mM) of creatinine in 25 ml of anhydrous DMF was added with stirring 1.78 g (12.8 mM) of 5-methyl-2-thienyl isocyanate in 12 ml of toluene. After 6 hrs. at 60° C., the mixture was cooled, poured into 100 ml of water and filtered. The collected solid was recrystallized twice from ethyl acetate to give 2.4 g of the above urea as a yellow-orange solid, m.p. 207°-209° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04230713 |
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| 출처 데이터셋 | uspto-grants-1980_10 |
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| ORD ID | ord-d5b88829eb5b4d9cb5be609cfccd79fd |
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| 출처 메모 | uspto-grants-1980_10 |
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