Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 904168생성일: 2026년 10월 27일
creatinine → 1-(3-Methyl-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea
https://huagongshe.com/reaction/904168
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | creatinine | HCID 588 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Isocyanato-3-methylthiophene | HCID 23361759 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(3-Methyl-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea | HCID 136098953 | 17.9% |
반응 단계
To a stirred suspension of 3.0 g (26.0 mM) of creatinine in 50 ml of anhydrous DMF was added dropwise a solution of 3.7 g (26 mM) of 3-methyl-2-thienyl isocyanate in 35 ml of toluene. After stirring at 90° C. for 6 hrs., the reaction mixture was cooled and poured into 100 ml of water. The separated solid was collected, washed with water and recrystallized from ethyl acetate to give 1.2 g of the above urea as a grey-white solid, m.p. 201°-202° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04230713 |
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| 출처 데이터셋 | uspto-grants-1980_10 |
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| ORD ID | ord-ff64be56b72740abae71f626cc372c44 |
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| 출처 메모 | uspto-grants-1980_10 |
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