2-(4-Iodophenyl)-2-methyloxirane → 2-(4-Iodophenyl)propanal

HRID 904234노트

반응식

HRID 904234 반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:11])[CH2:10][O:9]2)=[CH:4][CH:3]=1>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:11])[CH:10]=[O:9])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 233338282-(4-Iodophenyl)-2-methyloxirane

생성물 1

HCID 233338292-(4-Iodophenyl)propanal수율 83.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 15 g of 2-(4-iodophenyl)-2-methyloxirane in 75 ml of toluene was added 1.5 g of powdered Molecular Sieves 4A and the mixture was heated under reflux for 4 hours. After completion of the reaction, the Molecular Sieves was removed by filtration and the filtrate was concentrated and then distilled under reduced pressure to obtain 12.5 g (83% yield) of 2-(4-iodophenyl)propionaldehyde in oily form.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customAfter completion of the reaction
  4. customthe Molecular Sieves was removed by filtration
  5. concentrationthe filtrate was concentrated
  6. distillationdistilled under reduced pressure

출처 및 근거

ORD 기록
ord-8999572f3d574904bd9d0f42ab6d2142
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230719

반응 노트

불러오는 중…