Methanol → Methyl 16-bromohexadecanoate

HRID 904239노트

반응식

HRID 904239 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].S(=O)(=O)(O)O.[CH3:25]O>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:25])=[O:18]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 62039716-Bromohexadecanoic acid

생성물 1

HCID 2736822Methyl 16-bromohexadecanoate

실험 절차

A mixture of 22 g. of 16-bromohexadecanoic acid and 200 ml. of methanol is treated with 1.0 ml. of concentrated sulfuric acid and stirred under reflux for 24 hours. The mixture is treated with 10 g. of sodium acetate and the solvent is evaporated. The residue is partially soluble in 300 ml. of ether and the mixture is filtered. The ether solution is dried over magnesium sulfate and evaporated. The residue is crystallized from petroleum ether to yield methyl 16-bromohexadecanoate as a white solid.

후처리

  1. additionA mixture of 22 g
  2. temperatureunder reflux for 24 hours
  3. additionThe mixture is treated with 10 g
  4. customof sodium acetate and the solvent is evaporated
  5. filtrationof ether and the mixture is filtered
  6. dry with materialThe ether solution is dried over magnesium sulfate
  7. customevaporated
  8. customThe residue is crystallized from petroleum ether

출처 및 근거

ORD 기록
ord-f4ba8ebe536549c6841d773d53066c8a
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230628

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