p-(15-Carbomethoxypentadecylamino)benzoic acid → 4-(15-Carbomethoxypentadecylamino)benzoyl chloride hydrochloride

HRID 904251노트

반응식

HRID 904251 반응식
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][CH:22]=1)([O:3][CH3:4])=[O:2].C(COC)OC.C(Cl)[Cl:37]>>[ClH:37].[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([Cl:37])=[O:26])=[CH:23][CH:22]=1)([O:3][CH3:4])=[O:2]

참가 물질

3

반응물 2

HCID 12898273p-(15-Carbomethoxypentadecylamino)benzoic acidHCID 86634710Dimethoxyethane methylene chloride

생성물 1

HCID 211632694-(15-Carbomethoxypentadecylamino)benzoyl chloride hydrochloride

실험 절차

A cold solution of 25 g. of 4(15-carbomethoxypentadecylamino)benzoic acid in 500 ml. of dimethoxyethane-methylene chloride (4:1) is prepared and dry hydrochloric acid is bubbled through the solution until no more precipitate forms. The solution is treated with 25 ml. of thionyl chloride and refluxed until all of the precipitate has redissolved. The solvents are evaporated to yield an orange, semi-crystalline mass.

후처리

  1. customdry hydrochloric acid is bubbled through the solution until no more precipitate forms
  2. additionThe solution is treated with 25 ml
  3. temperatureof thionyl chloride and refluxed until all of the precipitate
  4. dissolutionhas redissolved
  5. customThe solvents are evaporated
  6. customto yield an orange, semi-crystalline mass

출처 및 근거

ORD 기록
ord-24d483e144804dbeb17bc3d9d16052d6
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230628

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