N-(1,1-Dimethylethyl)benzenemethanamine → HCID 20458608, 화합물

HRID 904663

반응식

HRID 904663 반응식
C(NC(OC1C=C(C(=O)C[Br:21])C=C(OC(=O)NCC)C=1)=O)C.[CH2:23]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[BrH:21].[CH2:23]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

4

반응물 2

HCID 76908N-(1,1-Dimethylethyl)benzenemethanamineHCID 204586013',5'-bis-(N-ethylcarbamoyloxy)-2-bromo acetophenone

생성물 1

HCID 20458608HCID 20458608, 화합물수율 78.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 8.0 g of 3',5'-bis-(N-ethylcarbamoyloxy)-2-bromo acetophenone in 100 ml of acetone was added 7.0 g of N-benzyl-t-butylamine. The mixture was refluxed for 18 hours. The 4.1 g of N-benzyl-t-butylamine hydrobromide formed and precipitated during the reaction was filtered off and the filtrate was acidified with conc HCl. The filtrate was now evaporated to dryness and the title compound was isolated by column chromatography on Silica gel 60 using 1) CHCl3 /ethanol (2:1), 2) ethanol as eluants. The title compound was eluted in the ethanol fraction and recrystallized from ethanol/diethylether. The identity of the product was confirmed with NMR.

후처리

  1. temperatureThe mixture was refluxed for 18 hours

출처 및 근거

ORD 기록
ord-2c26adbca5da4cac866dbebb3bdc88d7
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04419364

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