Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methane → 5-Chloro-2-[(2-methylphenyl)methyl]-1H-benzimidazole-6-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methane | HCID 297 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-(o-Tolyl)acetonitrile | HCID 31155 | — |
| 반응물 | 4,5-Diamino-2-chlorobenzene-1-sulfonamide | HCID 13289688 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-Chloro-2-[(2-methylphenyl)methyl]-1H-benzimidazole-6-sulfonamide | HCID 13289710 | — |
반응 단계
To 50 ml of 6 N hydrochloric acid was added 11.8 g of 2-amino-4-chloro-5-sulfamylaniline and 10.4 g of 2-methylbenzyl cyanide. The reaction was refluxed for 22 hours and then concentrated in vacuo to a solid which was then added with stirring to 200 ml of 38% ammonium hydroxide. Filtration provided the free base as a semi-gum which was dissolved in 500 ml of methanol. The methanol solution was brought to a boil, charcoal added, and boiling continued for five minutes. Upon cooling, the suspension was filtered through Celite and the filtrate concentrated in vacuo to yield a solid, m.p. 226°-230°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04420487 |
| 출처 데이터셋 | uspto-grants-1983_12 |
| ORD ID | ord-cb0c1604acbf44a68236af1dde3cf798 |
| 출처 메모 | uspto-grants-1983_12 |