4-(6-Methoxy-2-naphthalenyl)-3-buten-2-one → Nabumetone

HRID 904938

반응식

HRID 904938 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]=[CH:14][C:15](=[O:17])[CH3:16])[CH:7]=[CH:6]2.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][CH2:14][C:15](=[O:17])[CH3:16])[CH:7]=[CH:6]2

참가 물질

5

반응물 2

HCID 534099264-(6-Methoxy-2-naphthalenyl)-3-buten-2-oneHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 4409Nabumetone수율 69.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

4-(6-Methoxy-2-naphthyl)-3-butene-2-one (32 g) in ethyl acetate (500 ml) was shaken at room temperature over 10% Pd/C (3 g) under atmospheric pressure hydrogen until no further uptake of hydrogen occurred to yield 4-(6-methoxy-2-naphthyl)butan-2-one (22.5 g), mp. 78.5° C.

출처 및 근거

ORD 기록
ord-2d41f0e4ef95449290297d6d08cfd8ca
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04420639

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