Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylmorpholine → Z-Ile-Phe-OBut
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylmorpholine | HCID 7525 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | N-[(Phenylmethoxy)carbonyl]-L-isoleucine | HCID 2724772 | — |
| 반응물 | tert-butyl (2S)-2-amino-3-phenylpropanoate | HCID 6931633 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Z-Ile-Phe-OBut | HCID 131713277 | — |
반응 단계
1.3 ml of N-ethylmorpholine are added to the solution of 2.65 g of Z-Ile-OH, 2.58 g of H-Phe-OBut and 1.35 g of HOBt in 30 ml of dimethylformamide and 2.2 g of DCC are added to 0° C. The mixture is allowed to stand for 1 hour at 0° C. and overnight at room temperature. On the following day the precipitate is filtered off and the filtrate is concentrated. The residue is partitioned between ethyl acetate and water. The ethyl acetate phase is extracted by shaking with 20 ml of saturated NaHCO3 solution, 20 ml of K2SO4 /KHSO4 solution and 20 ml of NaHCO3 solution and is dried over Na2SO4 and concentrated. The product crystallizes from petroleum ether. Yield 3.7 g, melting point 122°-125°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04420424 |
| 출처 데이터셋 | uspto-grants-1983_12 |
| ORD ID | ord-a9eaf38e2fd04680b6ed72562a431c04 |
| 출처 메모 | uspto-grants-1983_12 |