Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorophenol → 2-(4-fluorophenoxymethyl)-3,4-dihydro-2H-pyran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorophenol | HCID 9732 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (3,4-dihydro-2H-pyran-2-yl)methyl 4-methylbenzene-1-sulfonate | HCID 13071283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(4-fluorophenoxymethyl)-3,4-dihydro-2H-pyran | HCID 20476940 | 24.5% |
반응 단계
A mixture of a solution of 247 mg of p-fluorophenol in 1 ml of dimethylformamide with 87 mg of 55% sodium hydride was stirred at room temperature for 30 minutes. 537 mg of 2-tosyloxymethyl-3,4-dihydro-2H-pyran were then added to the mixture, which was allowed to react at 90° C. for 3 hours. Thereafter, the mixture was treated and the product purified essentially as described in Example 34(a) to give 102 mg of 2-(4-fluorophenoxymethyl)-3,4-dihydro-2H-pyran as a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04421758 |
| 출처 데이터셋 | uspto-grants-1983_12 |
| ORD ID | ord-8cb04b93492a4aa497b3647dccf235ea |
| 출처 메모 | uspto-grants-1983_12 |