HCID 14203475, 화합물 → 2-(4-aminophenyl)-5,6-dihydro-4H-1,3,4-oxadiazin-5-one

HRID 905178노트

반응식

HRID 905178 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 14203475HCID 14203475, 화합물

생성물 1

HCID 147428442-(4-aminophenyl)-5,6-dihydro-4H-1,3,4-oxadiazin-5-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2-p-nitrophenyl-4H,6H-1,3,4-oxadiazin-5-one (Example 17; 2.2 g.) in ethyl acetate (250 ml.) was hydrogenated in the prsence of a 5% palladium-on-charcoal catalyst at laboratory temperature and atmospheric pressure until 670 ml. of hydrogen had been absorbed. The mixture was filtered and the filtrate was evaporated to dryness. There was thus obtained as solid residue 2-p-aminophenyl-4H,6H-1,3,4-oxadiazin-5-one, m.p. 253°-255° C. (with decomposition).

후처리

  1. customof hydrogen had been absorbed
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-f58116059e5940ad8278e134a5d95d66
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04423045

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