m-Chloroperbenzoic acid → NY 4138

HRID 905232노트

반응식

HRID 905232 반응식
ClC1C=CC=C(C(OO)=[O:9])C=1.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH2:17][S:18][C:19]1[N:24]=[CH:23][C:22]([Br:25])=[CH:21][N:20]=1>ClCCl>[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH2:17][S:18]([C:19]1[N:24]=[CH:23][C:22]([Br:25])=[CH:21][N:20]=1)=[O:9]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 20475699HCID 20475699, 화합물

생성물 1

HCID 133258NY 4138수율 53%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

85% m-Chloroperbenzoic acid (1.5 mmol) was added to a solution of 2-(2-thienylmethylthio)-5-bromopyrimidine (1.5 mmol) in dichloromethane (25 ml) at -10° C. and the solution left at 0° C. for 18 h. The dichloromethane solution was then washed with saturated aqueous solutions of Na2SO and NaHCO3, and the dried (MgSO4) solution evaporated to leave the title compound; yield 53%, m.p. 108°-109° C. (iPrOH). 1H NMR (CDCl3) δ4.53 (CH2, 6.9 (H-3', H-4'), 7.16 (H-5'), 8.83 (H-4, H-6).

후처리

  1. washThe dichloromethane solution was then washed with saturated aqueous solutions of Na2SO and NaHCO3
  2. dry with materialthe dried (MgSO4) solution
  3. customevaporated

출처 및 근거

ORD 기록
ord-8ca5d55e1db345b4930439a0518b6115
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04423047

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