Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → 3-[4-(8-Cyclohexyloctylamino)benzoyl]carboxythiazolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | Timonacic | HCID 9934 | — |
| 반응물 | Ethyl thiazolidine-4-carboxylate | HCID 103574 | — |
| 반응물 | p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride | HCID 20475769 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | Acetone sodium bicarbonate | HCID 86737261 | — |
| 생성물 | 3-[4-(8-Cyclohexyloctylamino)benzoyl]carboxythiazolidine | HCID 20475813 | — |
반응 단계
One-tenth mole of 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is crystallized from acetonitrile. By means of the alkaline hydrolysis method of Example 1, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04423051 |
| 출처 데이터셋 | uspto-grants-1983_12 |
| ORD ID | ord-8408e481869f486cbfd60bce4bb9ab27 |
| 출처 메모 | uspto-grants-1983_12 |