Triethylamine → Methanesulphonylpyrazoline

HRID 905324

반응식

HRID 905324 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH:6]1[CH2:10][CH:9]=[CH:8][NH:7]1.C(N(CC)CC)C>C(Cl)Cl>[CH3:1][S:2]([N:7]1[CH2:8][CH:9]=[CH:10][NH:6]1)(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 41560032,3-dihydro-1H-pyrazole

생성물 1

HCID 54062380Methanesulphonylpyrazoline수율 77%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

114.5 g of methanesulphonic acid chloride were added dropwise to 70 g of pyrazoline and 101 g of triethylamine in 300 ml of methylene chloride at room temperature. The mixture was subsequently stirred at room temperature for 3 hours and was filtered. The filtrate was washed with water, dried over sodium sulphate and concentrated. 114 g (77% of theory) of methanesulphonylpyrazoline of melting point 62° C. were obtained.

후처리

  1. filtrationwas filtered
  2. washThe filtrate was washed with water
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a07ead0b1aaa4c1bb2f33c4ae7d2feac
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04423225

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