3-methyl-N-(1-methylethyl)-2-nitrobenzeneacetamide → 2-amino-3-methyl-N-(1-methylethyl)benzeneacetamide
반응식
[CH3:1][C:2]1[C:3]([N+:15]([O-])=O)=[C:4]([CH2:8][C:9]([NH:11][CH:12]([CH3:14])[CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1>[Pd].C(O)C>[NH2:15][C:3]1[C:2]([CH3:1])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:8][C:9]([NH:11][CH:12]([CH3:14])[CH3:13])=[O:10]참가 물질
4
실험 절차
To 3-methyl-N-(1-methylethyl)-2-nitrobenzeneacetamide (i.e. the title product of Step A) (0.40 g, 1.7 mmol) and 10% palladium on carbon (0.13 g) was added 20 mL of ethanol. The reaction mixture was placed under a balloon of nitrogen overnight. Then the reaction mixture was filtered through Celite® diatomaceous filter aid. The solvent was removed with a rotary evaporator to afford the title compound as a tan solid (0.29 g).
후처리
- customwas placed under a balloon of nitrogen overnight
- filtrationThen the reaction mixture was filtered through Celite® diatomaceous filter aid
- customThe solvent was removed with a rotary evaporator
출처 및 근거
- ORD 기록
- ord-724fa7862a134c53b681cc5d9fd722e1
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08012499B2
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