Ethanolamine → 2-{[2-(6-Amino-2-butoxy-8-methoxy-9H-purin-yl)ethyl]amino}ethanol

HRID 905636노트

반응식

HRID 905636 반응식
Br[CH2:2][CH2:3][N:4]1[C:12]([O:13][CH3:14])=[N:11][C:10]2[C:5]1=[N:6][C:7]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])=[N:8][C:9]=2[NH2:15].[NH2:21][CH2:22][CH2:23][OH:24]>C(#N)C>[NH2:15][C:9]1[N:8]=[C:7]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])[N:6]=[C:5]2[C:10]=1[N:11]=[C:12]([O:13][CH3:14])[N:4]2[CH2:3][CH2:2][NH:21][CH2:22][CH2:23][OH:24]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 589428939-(2-Bromoethyl)-2-butoxy-8-methoxy-9H-purin-6-amine

생성물 1

HCID 585519292-{[2-(6-Amino-2-butoxy-8-methoxy-9H-purin-yl)ethyl]amino}ethanol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
70 °C

실험 절차

To the compound obtained by Example 2-39 step (i) (300 mg) in acetonitrile (5 ml) was added 2-aminoethanol (265 mg) and heated at 70° C. for 24 hours. The reaction mixture was purified by column chromatography (ethyl acetate: 7N ammonia-methanol 95:5) to give the titled compound. Yield: 295 mg (100%).

후처리

  1. customThe reaction mixture was purified by column chromatography (ethyl acetate: 7N ammonia-methanol 95:5)

출처 및 근거

ORD 기록
ord-161d27d6f2a74315bf21b34e33f53b66
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012964B2

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