tert-Butyl (3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-3-hydroxypropyl)carbamate → Ethyl 5-{[(tert-butoxy)carbonyl]amino}-3-oxopentanoate

HRID 905770노트

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HRID 905770 반응식
[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][CH2:9][C:10](=[C:12]1C(=O)O[C:15](C)([CH3:19])[O:14][C:13]1=[O:21])[OH:11])([CH3:4])([CH3:3])[CH3:2]>C(O)C>[CH2:15]([O:14][C:13](=[O:21])[CH2:12][C:10](=[O:11])[CH2:9][CH2:8][NH:7][C:6]([O:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[O:22])[CH3:19]

참가 물질

3

반응물 1

HCID 54704545tert-Butyl (3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-3-hydroxypropyl)carbamate

생성물 1

HCID 10061105Ethyl 5-{[(tert-butoxy)carbonyl]amino}-3-oxopentanoate수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A stirred solution of [3-(2,2-dimethyl-4,6-dioxo-[1,3]dioxin-5-ylidene)-3-hydroxy-propyl]-carbamic acid tert-butyl ester in absolute ethanol (112 ml) was heated to reflux at 70° C. overnight, and cooled to room temperature. The mixture was filtered and concentrated under reduced pressure to give 5-tert-butoxycarbonylamino-3-oxo-pentanoic acid ethyl ester (11.22 g, 87%) as a white solid.

후처리

  1. temperaturecooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4bde95bb6b014471bbb9fb4aa7e45804
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012966B2

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