Trifluoroacetic acid methylene chloride → HCID 67414694, 화합물

HRID 906037노트

반응식

HRID 906037 반응식
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=C)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(Cl)Cl.[C:36]([OH:42])([C:38]([F:41])([F:40])[F:39])=[O:37]>>[F:39][C:38]([F:41])([F:40])[C:36]([O-:42])=[O:37].[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][NH2+:23][CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=[O:37])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 57439883HCID 57439883, 화합물

생성물 1

HCID 67414694HCID 67414694, 화합물수율 95%

실험 절차

tert-butyl 4-[4-(1-{[4-(acetyloxy)phenyl]amino}vinyl)phenyl]piperazine-1-carboxylate (0.1 M) in a solution of DCM/TFA (2/3) was stirred at RT for 30 min. The organic solvent was evaporated in vacuo and the crude residue was scratched with Et2O. The resultant white solid precipitate was filtered off to afford the title compound (95%); MS (ES+) m/z 339 (M+H)+

후처리

  1. customThe organic solvent was evaporated in vacuo
  2. filtrationThe resultant white solid precipitate was filtered off

출처 및 근거

ORD 기록
ord-a9eb63e8e30246309e29765be4102858
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012982B2

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