HCID 67403053, 화합물 → HCID 22402069, 화합물

HRID 906111노트

반응식

HRID 906111 반응식
[NH2:1][C:2]([C:4]1[CH:16]=[CH:15][C:7]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[CH:6][C:5]=1[N+:17]([O-])=O)=[O:3]>[Pd].C(OCC)(=O)C>[NH2:17][C:5]1[CH:6]=[C:7]([CH:15]=[CH:16][C:4]=1[C:2]([NH2:1])=[O:3])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]

참가 물질

4

반응물 1

HCID 67403053HCID 67403053, 화합물

생성물 1

HCID 22402069HCID 22402069, 화합물수율 95.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 1,1-dimethylethyl 4-(aminocarbonyl)-3-nitrobenzoate (213 mg, 0.80 mmol), 10% palladium on charcoal (Degussa type, 200 mg) in ethyl acetate (20 mL) was shaken in a Parr hydrogenation apparatus at 35 psi for 4 hours. The reaction mixture was filtered and concentrated to give 1,1-dimethylethyl 3-amino-4-(aminocarbonyl)benzoate (180 mg, 95% yield). MS (EI) for C12H16N2O3: 237 (MH+).

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-523d6bf1bb2843eb8b13e0421aa44763
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012956B2

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