Potassium Carbonate → Tert-butyl 4-({2-(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-1-oxo-1,2-dihydroisoquinolin-4-yl}sulfanyl)piperidine-1-carboxylate

반응식

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][C:14]([CH3:25])([CH3:24])[CH2:15][O:16][Si:17]([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18])[CH:6]=[C:5]2[S:26][CH:27]1[CH2:32][CH2:31][N:30]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:29][CH2:28]1.[CH:40]1([NH:43][C:44](=[O:62])[C:45]2[CH:50]=[C:49](B3OC(C)(C)C(C)(C)O3)[C:48]([CH3:60])=[C:47]([F:61])[CH:46]=2)[CH2:42][CH2:41]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Si:17]([O:16][CH2:15][C:14]([CH3:25])([CH3:24])[CH2:13][N:7]1[CH:6]=[C:5]([S:26][CH:27]2[CH2:32][CH2:31][N:30]([C:33]([O:35][C:36]([CH3:38])([CH3:37])[CH3:39])=[O:34])[CH2:29][CH2:28]2)[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([C:49]3[CH:50]=[C:45]([C:44](=[O:62])[NH:43][CH:40]4[CH2:41][CH2:42]4)[CH:46]=[C:47]([F:61])[C:48]=3[CH3:60])[CH:3]=2)[C:8]1=[O:12])([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:18])[CH3:19]