Diethyl Ether → 3-(3-Pyridinyl)benzoic acid hydrazide

HRID 906825노트

반응식

HRID 906825 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10](OC)=[O:11])[CH:2]=1.[NH2:17][NH2:18].C(OCC)C>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([NH:17][NH2:18])=[O:11])[CH:2]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 9321HydrazineHCID 4133188Methyl 3-(3-pyridinyl)benzoate

생성물 1

HCID 591273483-(3-Pyridinyl)benzoic acid hydrazide수율 35%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of methyl 3-(pyridin-3-yl)benzoate (190 mg, 0.89 mmol) in anhydrous methanol (1 mL) was added hydrazine (0.07 mL,). The solution was stirred at RT overnight before ethyl ether was added. The solid was filtered and washed with ethyl ether to give 67 mg (35% yield) of 3-(pyridin-3-yl)benzohydrazide as a white solid. An additional 120 mg of the product was recovered from the filtrate. (M+H)+=214.13

후처리

  1. additionwas added
  2. filtrationThe solid was filtered
  3. washwashed with ethyl ether

출처 및 근거

ORD 기록
ord-ed4813d52ee44a4c93424668940f0b57
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013004B2

반응 노트

불러오는 중…