Potassium Carbonate → (E)-4-(2,4-difluorophenyl)but-3-en-2-one
반응식
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.COP([CH2:17][C:18](=[O:20])[CH3:19])(=O)OC.C([O-])([O-])=O.[K+].[K+]>O>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1/[CH:4]=[CH:17]/[C:18](=[O:20])[CH3:19]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
A two necked flask was charged with 2,4-difluorobenzaldehyde (4.0 g, 28.1 mmol) and (2-oxo-propyl)-phosphonic acid dimethyl ester (5.78 g, 33.0 mmol) and cooled down at at 0° C. K2CO3 (7.62 g, 55.1 mmol) in H2O (14 mL) was added dropwise. Stirring was continued over night at RT. The product was extracted with EtOAc, and the organic phase was dried over Na2SO4. Flash chromatography (SiO2, Heptane/EtOAc 1:3) afforded 4.0 g (79%) of the title compound as alight yellow oil.
후처리
- waitwas continued over night at RT
- extractionThe product was extracted with EtOAc
- dry with materialthe organic phase was dried over Na2SO4
출처 및 근거
- ORD 기록
- ord-d7fe75a336c5485ba0790a67c405a0ba
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08012998B2
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