Cerium(III) chloride → benzyl (2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate

HRID 906949노트

반응식

HRID 906949 반응식
[Cl-].[Ce+3].[Cl-].[Cl-].[CH2:5]([Mg]Br)[CH3:6].C(OCC)C.[CH3:14][C@H:15]1[C:19](=[O:20])[CH2:18][CH2:17][N:16]1[C:21]([O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22]>>[CH2:15]([C@:19]1([OH:20])[CH2:18][CH2:17][N:16]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[C@H:5]1[CH3:6])[CH3:14]

참가 물질

4

반응물 3

HCID 24636Cerium(III) chlorideHCID 59556933benzyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylateHCID 178467792HCID 178467792, 화합물

생성물 1

HCID 59273017benzyl (2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate

실험 절차

By an operation in the same manner as in Reference Example 3 and using cerium chloride (7.94 g), 3 mol/L ethylmagnesium bromide-diethyl ether solution (9.46 mL) and benzyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate (3.0 g), the title compound was obtained as pale-yellow oil (yield: 1.96 g, yield: 58%).

출처 및 근거

ORD 기록
ord-cbc6388bfc3442c09f27a9cd173ec59d
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013008B2

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