benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate → (2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

HRID 906961노트

반응식

HRID 906961 반응식
[OH:1][C@@:2]1([CH3:20])[CH2:6][CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[C@H:3]1[CH:17]([CH3:19])[CH3:18]>O>[CH:17]([C@H:3]1[C@@:2]([CH3:20])([OH:1])[CH2:6][CH2:5][NH:4]1)([CH3:19])[CH3:18]

참가 물질

3

반응물 1

HCID 59273084benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate

생성물 1

HCID 59273040(2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate (1.78 g) and 50% water containing −10% Pd/C (0.09 g), the title compound was obtained as a colorless solid (yield: 1.07 g, yield: 89%).

출처 및 근거

ORD 기록
ord-ef38d6cc78fc4ae899931dfecc2f47c7
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013008B2

반응 노트

불러오는 중…