benzyl (2S,3R)-3-cyclopropyl-2-ethyl-3-hydroxypyrrolidine-1-carboxylate → (2S,3R)-3-cyclopropyl-2-ethylpyrrolidin-3-ol

HRID 906973노트

반응식

HRID 906973 반응식
[CH:1]1([C@:4]2([OH:21])[CH2:8][CH2:7][N:6](C(OCC3C=CC=CC=3)=O)[C@H:5]2[CH2:19][CH3:20])[CH2:3][CH2:2]1>[Pd].O>[CH:1]1([C@:4]2([OH:21])[CH2:8][CH2:7][NH:6][C@H:5]2[CH2:19][CH3:20])[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 59273035benzyl (2S,3R)-3-cyclopropyl-2-ethyl-3-hydroxypyrrolidine-1-carboxylate

생성물 1

HCID 59273036(2S,3R)-3-cyclopropyl-2-ethylpyrrolidin-3-ol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3R)-3-cyclopropyl-2-ethyl-3-hydroxypyrrolidine-1-carboxylate (2.01 g) and 50% water containing-10% Pd/C (0.20 g), the title compound was obtained as a colorless solid (yield: 1.35 g, yield: 96%).

출처 및 근거

ORD 기록
ord-48273e646f5e4254adbad3d003064ed4
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013008B2

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