benzyl (2RS,3SR)-3-hydroxy-2,4,4-trimethylpyrrolidine-1-carboxylate → 2,4,4-Trimethylpyrrolidin-3-OL

HRID 906978노트

반응식

HRID 906978 반응식
[OH:1][CH:2]1[C:6]([CH3:8])([CH3:7])[CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[CH:3]1[CH3:19]>CO.[C].[Pd]>[CH3:19][CH:3]1[CH:2]([OH:1])[C:6]([CH3:8])([CH3:7])[CH2:5][NH:4]1

참가 물질

4

반응물 1

HCID 67390300benzyl (2RS,3SR)-3-hydroxy-2,4,4-trimethylpyrrolidine-1-carboxylate

생성물 1

HCID 673891462,4,4-Trimethylpyrrolidin-3-OL수율 123.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A suspension (20 mL) of benzyl (2RS,3SR)-3-hydroxy-2,4,4-trimethylpyrrolidine-1-carboxylate (842 mg) and 10% palladium carbon (50% water-containing, 110 mg) in methanol was stirred under a hydrogen atmosphere for 1.5 hr. The reaction mixture was filtered, oxalic acid (144 mg) was added to the filtrate, and the mixture was concentrated under reduced pressure to give the title compound as a colorless solid (yield: 512 mg, yield: 92%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. additionoxalic acid (144 mg) was added to the filtrate
  3. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4daf305b659f411fa9683d67ad96b6d0
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013008B2

반응 노트

불러오는 중…