Trifluoroacetic acid → (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol

HRID 907012노트

반응식

[OH:1][C@@:2]1([CH:15]=[CH2:16])[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C@H:3]1[CH3:14].FC(F)(F)C(O)=O>>[CH3:14][C@H:3]1[C@@:2]([CH:15]=[CH2:16])([OH:1])[CH2:6][CH2:5][NH:4]1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 59273002tert-butyl (2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidine-1-carboxylate

생성물 1

HCID 67389951(2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol수율 306.2%

실험 절차

To tert-butyl (2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidine-1-carboxylate (684 mg, 2.85 mmol) was added trifluoroacetic acid (3.0 ml). The mixture was stirred at room temperature for 15 min, and concentrated under reduced pressure to give (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol (yield: 1.11 g).

후처리

concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-aa41fda9d38d476cb44fa4e50a020064
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08013008B2

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