3-Hydroxybenzyl alcohol → {3-[3-(Dimethylamino)propoxy]phenyl}methanol
반응식
C(=O)([O-])[O-].[Cs+].[Cs+].[OH:7][CH2:8][C:9]1[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1.Cl.Cl[CH2:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22].O>CN(C=O)C>[CH3:22][N:21]([CH3:23])[CH2:20][CH2:19][CH2:18][O:15][C:11]1[CH:10]=[C:9]([CH2:8][OH:7])[CH:14]=[CH:13][CH:12]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
Cesium carbonate (15.4 g) was added to a solution of 3-hydroxymethyl-phenol (3 g) in DMF (80 mL). To this mixture was added (3-chloro-propyl)-dimethyl-amine hydrochloride (4 g). The mixture was heated at 80° C. for 20 hours then allowed to cool. The reaction mixture was poured into water and extracted with ethyl acetate.
후처리
- temperatureto cool
- extractionextracted with ethyl acetate
출처 및 근거
- ORD 기록
- ord-71e4c966cb49405586c71b9ed62f7d0b
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08012979B2
반응 노트
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