홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

3-(Dimethylamino)-1-propanol → N-Cyclopropyl-3-(2-((6-(3-(dimethylamino)propoxy)pyridin-3-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

HRID 907265
노트
인쇄 미리보기

반응식

HRID 907265 반응식
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][OH:6].CC(C)([O-])C.[K+].Br[C:15]1[N:20]=[CH:19][C:18]([CH2:21][N:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[C:27]([C:32]4[CH:33]=[C:34]([CH:41]=[CH:42][C:43]=4[CH3:44])[C:35]([NH:37][CH:38]4[CH2:40][CH2:39]4)=[O:36])[CH:28]=3)[C:23]2=[O:45])=[CH:17][CH:16]=1>C1COCC1>[CH:38]1([NH:37][C:35](=[O:36])[C:34]2[CH:41]=[CH:42][C:43]([CH3:44])=[C:32]([C:27]3[CH:28]=[C:29]4[C:24](=[CH:25][CH:26]=3)[C:23](=[O:45])[N:22]([CH2:21][C:18]3[CH:19]=[N:20][C:15]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:7])[CH3:1])=[CH:16][CH:17]=3)[CH:31]=[CH:30]4)[CH:33]=2)[CH2:39][CH2:40]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 766463-(Dimethylamino)-1-propanolHCID 23665647Potassium tert-butoxideHCID 575517913-(2-((6-Bromopyridin-3-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

생성물 1

HCID 25019959N-Cyclopropyl-3-(2-((6-(3-(dimethylamino)propoxy)pyridin-3-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매
2회

실험 절차

To solution of 3-(dimethylamino)propan-1-ol (0.03 mL) in THF (1 mL) was added potassium tert-butoxide (28 mg) and the reaction stirred at room temperature for 10 minutes. A solution of the product of step i) (100 mg) in THF (2 mL) was added, and the mixture heated at reflux for 100 hours.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 100 hours

출처 및 근거

ORD 기록
ord-b31c8877c17f4865a849925393a56209
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08012979B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트